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June 1997

Latent Epstein-Barr Virus Infection Is Frequently Detected in Subcutaneous Lymphoma Associated With Hemophagocytosis but Not in Nonfatal Cytophagic Histiocytic Panniculitis

Author Affiliations

Department of Dermatology Fukushima Medical College 1-Hikarigaoka, Fukushima 960-12, Japan

Arch Dermatol. 1997;133(6):787-788. doi:10.1001/archderm.1997.03890420133022

We read with interest the article by Monterroso et al1 in a recent issue of the Archives. The authors described a patient with subcutaneous lymphoma who tested negative for Epstein-Barr virus (EBV) and stated that the majority of evidence to date suggests that cases of subcutaneous panniculitic T-cell lymphoma, many of which resemble cytophagic histiocytic panniculitis (CHP), are negative for EBV. As the opposite example, the authors referred to our previous report2 of a case of T-cell lymphoma with features of CHP, in which DNA for EBV was detected by polymerase chain reaction. An in situ hybridization study performed after publication revealed that our patient tested positive for EBV-encoded small RNAs in most infiltrating atypical cells (Figure). Furthermore, our screening test in 74 patients with lymphoproliferative disorders disclosed at least 2 additional cases of fatal subcutaneous lymphoma characterized by hemophagocytosis and latent EBV infection (Table). Cells with EBV-encoded

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