The acquired progressive kinking of scalp hair is a disorder in which affected hairs resemble secondary sexual hairs. Some authors have evoked an androgen-related disorder that heralds the onset of androgenetic alopecia. To verify this hypothesis, we focused our attention on a 23-year-old man who has this unusual disorder, which is progressing toward androgenetic alopecia. Patient's circulating 5α-reductase reduced androgen levels; scalp skin 5α-dihydrotestosterone formation; and trichography, histological, scanning, and polarizing electron microscopy analyses were compared in normal and affected scalp skin areas.
Results of histological and scalp skin 5α-dihydrotestosterone formation analyses and comparison of growth pattern of kinky hair in the affected areas with that of healthy hair were similar to those found in androgenetic alopecia.
No data are available to confirm the presence of a sole entity, even if our arguments support our hypothesis. The confirmation of this tendency warrants further investigation.Arch Dermatol. 1997;133:1129-1133
Boudou P, Reygagne P. Increased Scalp Skin and Serum 5a-Reductase Reduced Androgens in a Man Relevant to the Acquired Progressive Kinky Hair Disorder and Developing Androgenetic Alopecia. Arch Dermatol. 1997;133(9):1129–1133. doi:10.1001/archderm.1997.03890450079009
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: