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November 1997

A Self-healing Tumor on the Upper Lip

Author Affiliations

Hospital Clinic Barcelona, Barcelona, Spain

Arch Dermatol. 1997;133(11):1455-1456. doi:10.1001/archderm.1997.03890470133022

REPORT OF A CASE  A 49-year-old woman complained about a single, painful tumor located on her upper lip. It was firm, red, and ulcerated. The tumor had grown rapidly to 2 cm in diameter in 3 weeks (Figure 1). No other abnormality was found on physical examination. Lymphadenopathy was absent. No significant laboratory findings were present. A biopsy specimen was obtained for histopathologic examination (Figure 2 and Figure 3), and the tumor regressed 1 month later (Figure 4). Immunoperoxidase staining with CD30 antibodies is shown in Figure 5.What is your diagnosis?

DIAGNOSIS:  Primary cutaneous CD30+ large cell anaplastic T-cell lymphoma (LCAL).

HISTOPATHOLOGIC FINDINGS  The hematoxylin-eosin—stained sections showed an ulcerated tumor composed of a dense, nonepidermotropic, lymphoid infiltrate located in all levels of the dermis (Figure 3). The infiltrate was composed mainly of large cells with abundant cytoplasm and pleomorphic nucleus, with clear chromatin and 1 or more prominent nucleoli.