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November 1997

Pigmentary Demarcation Lines as Markers of Neural Development

Author Affiliations

Hôpital Pellegrin-Enfants 33076 Bordeaux, France

Arch Dermatol. 1997;133(11):1459. doi:10.1001/archderm.1997.03890470139025

We read with interest the comments by Krivo1 in a recent issue of the Archives about pigmentation demarcation lines (PDLs) and their relation to lines of Blaschko and cutaneous mosaicism. Krivo, who carefully reviewed the subject of PDLs in an article coauthored by Selmanowitz,2 considers now that PDLs follow lines of Blaschko, based on the diagrams published in the review by Bolognia et al.3 It is noteworthy that the latter authors did not consider PDLs as following lines of Blaschko.

The origin of PDLs has been addressed in studies by Miura4 and Dupré et al.5 Their conclusions were some- what different because the topography of PDLs was assigned to the axial lines of Sherrington. Those virtual lines, well studied by neurologists,6 correspond to a subset of lines of Voigt, which separate dermatomes arising from nonconsecutive dorsal roots (Figure). The lines may become visible only when