REPORT OF A CASE
A 63-year-old man presented with a large, 4-cm, superficial basal cell carcinoma (BCC) on the right side of the lower part of his back that had been present for 5 years (Figure, A). He refused surgical intervention.
We needed an effective nonsurgical treatment modality for this large BCC.
After giving his signed consent, the patient was treated with intralesional δ-aminolevulinic acid (ALA) photodynamic therapy (PDT). Two milliliters of 10% ALA in a 0.9% sodium chloride solution was injected intralesionally with a syringe. After light-shielding occlusion for 4 hours, visual evaluation of the treated lesion under Wood light in a darkened room revealed the typical red fluorescence of porphyrin limited to the tumor (Figure B). The lesion was then exposed to 180-J/cm2 fullspectrum visible light produced by a slide projector (Leica P-2000, Leica, Leitz Wetzlar, Germany) equipped with a 250-W lamp. There was
Fink-Puches R, Wolf P, Kerl H. Photodynamic Therapy of Superficial Basal Cell Carcinoma by Instillation of Aminolevulinic Acid and Irradiation With Visible Light. Arch Dermatol. 1997;133(12):1494–1495. doi:10.1001/archderm.1997.03890480014001
Customize your JAMA Network experience by selecting one or more topics from the list below.