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December 1997

Photodynamic Therapy of Superficial Basal Cell Carcinoma by Instillation of Aminolevulinic Acid and Irradiation With Visible Light

Arch Dermatol. 1997;133(12):1494-1495. doi:10.1001/archderm.1997.03890480014001

REPORT OF A CASE  A 63-year-old man presented with a large, 4-cm, superficial basal cell carcinoma (BCC) on the right side of the lower part of his back that had been present for 5 years (Figure, A). He refused surgical intervention.

THERAPEUTIC CHALLENGE  We needed an effective nonsurgical treatment modality for this large BCC.

SOLUTION  After giving his signed consent, the patient was treated with intralesional δ-aminolevulinic acid (ALA) photodynamic therapy (PDT). Two milliliters of 10% ALA in a 0.9% sodium chloride solution was injected intralesionally with a syringe. After light-shielding occlusion for 4 hours, visual evaluation of the treated lesion under Wood light in a darkened room revealed the typical red fluorescence of porphyrin limited to the tumor (Figure B). The lesion was then exposed to 180-J/cm2 fullspectrum visible light produced by a slide projector (Leica P-2000, Leica, Leitz Wetzlar, Germany) equipped with a 250-W lamp. There was

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