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December 1997

Phototherapy With UV-A-I for Generalized Granuloma Annulare

Author Affiliations

Photodermatology Section Department of Dermatology University Medical Center Freiburg D-79104 Freiburg, Germany

Arch Dermatol. 1997;133(12):1605. doi:10.1001/archderm.1997.03890480131025

Recently, long-wave UV-A radiation (340-400 nm) has been used to effectively treat patients with atopic dermatitis,1 localized scleroderma,2 and urticaria pigmentosa.3 We describe 4 patients with generalized granuloma annulare (GA) who responded to phototherapy with UV-A—I. Granuloma annulare is a benign, chronic, granulomatous skin disease of unknown origin. It is characterized by papular or granulomatous cutaneous lesions, usually distributed in an annular configuration.4 The skin lesions appear isolated or multiple as generalized GA on the trunk, face, arms, and legs.4 Although spontaneous resolution can occur in some cases, many different therapeutic modalities have been tried, including the use of topical or systemic corticosteroids, oral psoralen plus UV-A photochemotherapy, systemic retinoids, and dapsone, usually with poor results, particularly in generalized GA.4

In this study, 4 patients with histologically confirmed generalized GA participated after providing informed consent. All individuals had been treated for months with different