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December 1997

The Relationship Between Nitric Oxide Production and Activity of the Disease in Patients With Psoriasis

Author Affiliations

Department of Biochemistry Faculty of Medicine Karadeniz Technical University Biyokimya ABD 61080 Trabzon, Turkey


Arch Dermatol. 1997;133(12):1606-1607. doi:10.1001/archderm.1997.03890480132027

Psoriasis is a chronic inflammatory skin disease characterized by relapsing episodic inflammatory attacks. It is also associated with an increased prevalence of diabetes mellitus, hyperlipoproteinemia, hyperuricemia, and occlusive vascular involvement.1 During different phases of the disease, many of the cytokines and other inflammatory mediators derived from inflammatory cells, including macrophages and T lymphocytes, are released.2 The secretion rate of those mediators depends on the severity and duration of the cells. These events may be one of the factors responsible for the development of the previously mentioned disorders associated with psoriasis, and they also may affect the prognosis of the disease.

One of the mediators, the nitric oxide (NO) radical, is increasingly recognized as an important intracellular and intercellular messenger.3 A role for NO has been implicated in a variety of biological processes associated with increased circulating concentrations of cytokines and endotoxin. Whereas interleukin-1, interleukin-6, interleukin-8, tumor necrosis

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