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September 2007

Necrolytic Migratory Erythema: The Outermost Marker for Glucagonoma Syndrome

Arch Dermatol. 2007;143(9):1209-1226. doi:10.1001/archderm.143.9.1221

A 56-year-old woman presented with significant loss of weight, a painful oral inflammation, and a skin eruption on the trunk, lower extremities, and the intertriginous and genital areas. The physical examination showed a patient with cachexia and striking eruptions on the skin and mucous membranes. The lesions consisted of annular, confluent, superficially eroded erythematous plaques with elevated, well-demarcated edges and bullas at the sites of friction (Figure 1). Faint areas of lacy erythema were noted on the buttocks and arms. Severe stomatitis, painful glossitis, and bilateral angular cheilitis were present (Figure 2). Annular erythematous lesions with slightly elevated borders were seen on the genital area.