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Research Letter
November 2007

A Randomized Double-Blind Study of the Effect of Botox and Dysport/Reloxin on Forehead Wrinkles and Electromyographic Activity

Arch Dermatol. 2007;143(11):1447-1462. doi:10.1001/archderm.143.11.1447-b

The difference between the potency units of the 2 main botulinum toxin A products, Botox (Allergan, Irvine, California) and Dysport/Reloxin (Ipsen Ltd, Slough, England), is still a subject of discussion even after 15 years of clinical use. The manufacturer of Botox recommends higher ratios than does the manufacturer of Dysport/Reloxin. Herein, we report the findings of a randomized, double-blind, split-face study of forehead wrinkles and electromyographic (EMG) activity following application of the 2 products at a 3:1 dose ratio, independent of the support of either manufacturer.

Patients included in the study were aged 30 to 70 years, had moderate to severe hyperfunctional forehead wrinkles at rest and maximum contraction, and gave written informed consent. The study was approved by the institution's human research review committee.