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December 2007

Generalized Papules in a Patient With Acute Myeloid Leukemia—Diagnosis

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Copyright 2007 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2007

Arch Dermatol. 2007;143(12):1583-1588. doi:10.1001/archderm.143.12.1583-f

The skin biopsy specimen showed microabscesslike clusters of eosinophilic small round bodies within the blood vessels of the upper dermis. Periodic acid–Shiff and Grocott stains showed that these small bodies were positive for microorganisms. There were no microorganisms in the corneal layer. Parakeratosis, subtle dyskeratosis in the epidermis, and vacuolar change in the basal layer were also seen. A blood culture yielded Candida krusei. Based on these findings, we diagnosed these eruptions as fungal emboli due to systemic C krusei infection.