In this issue of the Archives, Kabashima et al1 describe a Japanese teenager with a hyperhidrotic, erythrodermic, transgredient nonsyndromic palmoplantar keratoderma (PPK). In finding phenotypic similarities with other patients formerly described in the Japanese dermatology literature, Kabashima and colleagues convincingly argue that their patient probably represents the recessive type of keratoderma first described by Nagashima et al2 in 1977. Autosomal recessive inheritance was speculated in view of the lack of parental transmission and the occurrence of the disease in multiple affected siblings.
Laurent Parmentier, Peter M. Steijlen, Maurice A. M. van Steensel. Recessive Palmoplantar KeratodermasA Fertile Biological Hunting Ground. Arch Dermatol. 2008;144(3):384–385. doi:10.1001/archderm.144.3.384