More than 25 years of accumulating evidence strongly implicates the immune system in the pathogenesis of psoriasis, including both acquired immunity (T cells) and innate host defense (macrophages, antigen-presenting cells, and keratinocytes). Psoriasis also has a strong genetic component, but the identity of the genes involved has largely remained obscure. In a study recently published in Nature Genetics,1 these 2 themes of psoriasis—genetics and immunology—come together in a coherent and clinically relevant way.
Nair RP, Ding J, Duffin KC, et al. Psoriasis Bench to Bedside: Genetics Meets Immunology. Arch Dermatol. 2009;145(4):462–464. doi:10.1001/archdermatol.2009.73
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