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April 2009

Dermoscopy of Cowden Syndrome

Author Affiliations

Copyright 2009 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2009

Arch Dermatol. 2009;145(4):508-509. doi:10.1001/archdermatol.2009.22

We describe 4 patients with known mutations in the PTEN gene (OMIM 158350) to illustrate the use of dermoscopy and the histologic appearance of palmar lesions in Cowden syndrome. The first case involved a 52-year-old woman with multiple small, skin-colored, smooth palmar keratotic macules (Figure 1); cases 2 and 3 involved 2 sisters, aged 31 and 32 years, with multiple small palmar keratotic macules (Figure 2 and Figure 3); and case 4 involved a 55-year-old woman with multiple small keratotic macules on her fingers (Figure 4A) and multiple white papules on the mucous membranes (Figure 4B).

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