Sweet syndrome (SS) is a reactive neutrophilic process characterized by tender, erythematous papules and plaques, fever, and leukocytosis and is associated with underlying infections, inflammatory diseases, and malignant neoplasms. To our knowledge, only 2 cases of SS associated with new-onset systemic lupus erythematosus (SLE) have been reported—one in an adult woman and the other in a 14-year-old girl.1,2 We report the first case in an adult man.