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May 2009

Epidermolytic Palmoplantar Keratoderma With Constriction Bands on Bilateral Fifth Toes

Arch Dermatol. 2009;145(5):609-610. doi:10.1001/archdermatol.2009.83

Epidermolytic palmoplantar keratoderma (EPPK) is an autosomal dominant skin disorder characterized by hyperkeratosis limited to the palms and soles and can be categorized into 2 types: Vörner and Unna-Thost types. The clinical expressions of the 2 types of EPPK are similar, but the histologic characteristics are different. Vörner type EPPK is characterized by vacuolar degeneration of keratinocytes in the upper spinous to granular layers. Unna-Thost EPPK can be distinguished from Vörner type because the Unna-Thost type lacks vacuolar degeneration.

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