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August 2009

Primary Treatment of Verrucous Carcinoma of the Penis With Fluorouracil, cis-Diamino-dichloro-platinum, and Radiation Therapy

Arch Dermatol. 2009;145(8):950-952. doi:10.1001/archdermatol.2009.160

The standard treatment for a verrucous carcinoma (also known as the giant condyloma of Buschke and Lowenstein) is surgical resection with 2-cm margins.1 For advanced or unresectable penile carcinoma, a number of chemotherapy agents including cisplatin, methotrexate, fluorouracil, and bleomycin have demonstrated modest activity. The Southwest Oncology Group2 performed the largest prospective clinical study of penile carcinoma and found an overall response rate of 32.5% and a complete response rate of 12.5%. It should be noted that this study was performed in patients with regionally advanced or metastatic squamous cell carcinoma (SCC). Based on improvements in chemoradiotherapy of nonpenile epithelial cancers, we evaluated whether this approach could be applied to a patient with advanced penile carcinoma who refused radical surgery.3,4

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