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October 2009

Large Amelanotic Melanoma and Vitiligo

Arch Dermatol. 2009;145(10):1198-1199. doi:10.1001/archdermatol.2009.249

Although the co-occurence of metastatic melanoma and vitiligolike depigmentation is well known, the complete causal relationship remains controversial.1 Antimelanoma antibodies may cross-react with antigens on normal melanocytes causing vitiligolike depigmentation that correlates with the extent and activity of disease.1 We herein describe the case of a young female patient who was living in Minsk during the Chernobyl nuclear disaster. The patient developed a giant primary amelanotic melanoma of the back that subsequently metastasized, and she developed classic vitiligolike depigmentation.

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