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Research Letter
Dec 2011

Evaluation of 4 Recently Discovered Human Polyomaviruses in Primary Cutaneous B-Cell and T-Cell Lymphoma

Author Affiliations

Author Affiliations: Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany (Drs Kreuter, Dewan, and St ücker); Institute of Virology, University of Cologne, National Reference Center for Papillomaviruses and Polyomaviruses, Cologne, Germany (Drs Silling and Wieland).

Arch Dermatol. 2011;147(12):1449-1451. doi:10.1001/archdermatol.2011.330

Primary cutaneous lymphomas make up a heterogeneous spectrum of cutaneous B-cell lymphomas (CBCLs) and cutaneous T-cell lymphomas (CTCLs) that affect the skin without extracutaneous disease at first diagnosis. The cause of these lymphomas remains largely unknown. Some epidemiologic findings such as old age and acquired or iatrogenic immunosuppression are suggestive for an infectious cause, especially in CTCL.1 However, all of the suspected agents, including retroviruses and herpesviruses, have failed to reveal a consistent association. The recent discovery of a novel polyomavirus (PyV) associated with Merkel cell carcinoma has rekindled research interest in the possibility that human PyVs (HPyVs) might induce cancer in humans. The present study was initiated to analyze a broad spectrum of CBCLs and CTCLs for the presence of 4 recently discovered cutaneous HPyVs.