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Infantile hemangiomas (IHs) are common vascular tumors of infancy. Although spontaneous involution is common, ulceration, scarring, recurrent bleeding, and obstruction of vital structures can complicate untreated IHs. Corticosteroids were the mainstay of treatment of IHs until recently, when the effectiveness of propranolol has been established. In this multicenter retrospective chart review, Price et al demonstrate that propranolol therapy was more clinically effective and cost-effective than oral corticosteroids in treating IHs. It also resulted in fewer surgical interventions and demonstrated better tolerance, suggesting that propranolol should be considered a first-line agent in treating IHs.
Nonmelanoma skin cancer (NMSC) is the most common malignant neoplasm in the United States, and the incidence has been rising over the past decades, particularly among young women. Epidemiologic evidence has established a clear association between solar radiation exposure and skin cancer. Exposure to UV-B radiation also results in cutaneous vitamin D synthesis. The relationship between vitamin D levels and NMSC is complex. In this cohort study, Eide et al demonstrated that an increased baseline serum 25-hydroxyvitamin D level was significantly associated with an increased NMSC risk. The authors describe the characteristics of a prospective cohort that would be essential to describe to elucidate the highly complex relationship between vitamin D and NMSC.
This Month in Archives of Dermatology. Arch Dermatol. 2011;147(12):1363. doi:10.1001/archdermatol.2011.504
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