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Research Letter
Jan 2012

Photodynamic Therapy With 5-Aminolevulinic Acid Intralesional Injection for Pyogenic Granuloma

Author Affiliations

Author Affiliations: Departments of Dermatology, Ajou University School of Medicine, Suwon (Drs Lee and Y. C. Kim), Kwandong University College of Medicine, Goyang (Dr E. H. Kim), and Kyungpook National University School of Medicine, Daegu (Dr Jang), South Korea.

Arch Dermatol. 2012;148(1):126-128. doi:10.1001/archderm.148.1.126

Various treatment techniques have been used to remove pyogenic granuloma (PG). However, surgical excision leaves scars, and other approaches such as curettage or shave excision with electrocautery appear less effective in clearing the lesion. The principal mechanisms associated with tumor destruction through photodynamic therapy (PDT) are direct destruction of tumor cells and indirect destruction of tumor-associated vasculature. Photodynamic therapy –mediated vascular effects range from transient vascular spasm, vascular stasis, and thrombus formation to permanent vessel occlusion and can include enhanced vascular leakiness.1 Recently, PDT has been effectively used to treat vascular lesions such as port-wine stains and Kaposi's sarcoma.2,3 However, to our knowledge, treatment of PG with PDT has not yet been reported. In this study, we investigate the effectiveness and safety of PDT with intralesional injection (ILI) of photosensitizer in the treatment of PG.