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Duval A, Dubertret L. Aprepitant as an antipruritic agent?  N Engl J Med. 2009;361(14):1415-141619797294PubMedGoogle ScholarCrossref
Torres T, Fernandes I, Selores M, Alves R, Lima M. Aprepitant: evidence of its effectiveness in patients with refractory pruritus continues.  J Am Acad Dermatol. 2012;66(1):e14-e1522177649PubMedGoogle ScholarCrossref
Ständer S, Siepmann D, Herrgott I, Sunderkötter C, Luger TA. Targeting the neurokinin receptor 1 with aprepitant: a novel antipruritic strategy.  PLoS One. 2010;5(6):e1096820532044PubMedGoogle ScholarCrossref
Gerber PA, Buhren BA, Homey B. More on aprepitant for erlotinib-induced pruritus.  N Engl J Med. 2011;364(5):486-48721288112PubMedGoogle ScholarCrossref
Wallengren J. Neuroanatomy and neurophysiology of itch.  Dermatol Ther. 2005;18(4):292-30316297000PubMedGoogle ScholarCrossref
Hill R. NK1 (substance P) receptor antagonists—why are they not analgesic in humans?  Trends Pharmacol Sci. 2000;21(7):244-24610871891PubMedGoogle ScholarCrossref
Mantyh PW. Neurobiology of substance P and the NK1 receptor.  J Clin Psychiatry. 2002;63:(suppl 11)  6-1012562137PubMedGoogle Scholar
Research Letter
Aug 2012

Topical Aprepitant in Clinical and Experimental Pruritus

Author Affiliations

Author Affiliations: Department of Dermatology, Skane University Hospital, Lund, Sweden.

Arch Dermatol. 2012;148(8):957-959. doi:10.1001/archdermatol.2012.1018

Peroral aprepitant is a nonpeptide inhibitor of tachykinin receptor NK1 approved for use as an antiemetic drug for chemotherapy-induced nausea. Duval and Dubertret1 first reported that peroral aprepitant effectively reduced pruritus in 3 patients with Sézary syndrome. Similar results were obtained later for 6 of 7 patients with erythrodermic cutaneous T-cell lymphoma.2 Ständer et al3 reported an open-label study of 20 patients with chronic pruritus treated for a week with peroral aprepitant. It has been suggested that the effects of aprepitant are related to its preventing of mast-cell activation in the skin.4 The aim of the present study was to test this hypothesis with topical aprepitant.