Customize your JAMA Network experience by selecting one or more topics from the list below.
Westerhof W, Relyveld GN, Kingswijk MM, de Man P, Menke HE. Propionibacterium acnes and the pathogenesis of progressive macular hypomelanosis. Arch Dermatol. 2004;140(2):210-214.
Progressive macular hypomelanosis is a common entity and is often mistaken for tinea versicolor and pityriasis alba; however, it is unresponsive to medications for these conditions. The authors of this interesting article had previously noted a red fluorescence of the follicles of affected skin in affected patients. Using biopsy specimens of lesional and healthy follicular skin as well as lesional and healthy interfollicular skin in 8 patients, they demonstrated gram-positive rods in the affected follicles but not in the unaffected follicles or the interfollicular skin. Culture of the affected follicles yielded Propionibacterium acnes in 7 of the 8 patients, while the unaffected follicles and the nonfollicular skin did not yield this organism. No spores or hyphae were visible in any biopsy specimens (stained with periodic acid–Schiff).
Pandya AG. Top Accessed Article: Propionibacterium Acnes and the Pathogenesis of Progressive Macular Hypomelanosis. Arch Dermatol. 2012;148(11):1256. doi:10.1001/archdermatol.2012.2177
Create a personal account or sign in to: