Customize your JAMA Network experience by selecting one or more topics from the list below.
Giacchero D, Ramacciotti C, Arnault JP, et al. A New Spectrum of Skin Toxic Effects Associated With the Multikinase Inhibitor Vandetanib. Arch Dermatol. 2012;148(12):1418–1420. doi:10.1001/2013.jamadermatol.192
Author Affiliations: Departments of Dermatology (Drs Giacchero, Arnault, Maksimovic, Mateus, and Robert), Pathology (Drs Tomasic and Wechsler), Endocrinology, and Nuclear Medicine (Dr Schlumberger), Gustave Roussy Institute, Villejuif, France; and Departments of Endocrinology and Nuclear Medicine, University of Paris-Sud, Villejuif (Dr Schlumberger).
Skin manifestations are among the most frequent adverse effects of targeted therapies.1 Hyperkeratosis and hand-foot skin reaction are observed with most raf and vascular endothelial growth factor (VEGF) inhibitors, whereas folliculitis is a hallmark of epidermal growth factor receptor (EGFR) blocking agents.1 Vandetanib (Zactima, ZD6474; AstraZeneca) is a multikinase inhibitor that targets EGFR, VEGF receptors 1, 2, and 3 and the RET (rearranged during transfection) receptor.2
Between November 2005 and October 2009, patients with metastatic thyroid cancer received vandetanib at a dose of 300 mg/d in 3 clinical trials: a phase 2 open-label study (NCT00098345)3 and 2 randomized phase 3 studies comparing vandetanib with a placebo (NCT00537095 and NCT00410761). Clinical examination of all patients exhibiting any skin manifestation was performed. Skin toxic effects were assessed using version 3 of the National Cancer Institute Common Terminology Criteria (http://ctep.cancer.gov/protocolDevelopment/electronic_applications/ctc.htm), and additional drug intake was recorded. All patients participating in this study provided a written informed consent for the clinical trials. This study was conducted according to the Declaration of Helsinki Good Clinical Practice guidelines and in accordance with applicable local laws and regulations.
Create a personal account or sign in to: