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Actinic keratoses are common in light-skinned individuals who spend significant time in geographic areas with moderate to high levels of solar radiation. Cryotherapy is the most widely used therapy for these premalignant lesions. Field therapies that treat the entire field of sun-damaged skin include fluorouracil, imiquimod, diclofenac, and photodynamic therapy. In this study, Lebwohl et al demonstrate that ingenol mebutate, the active ingredient in the sap of the plant Euphorbia peplus applied as a gel for 2 or 3 consecutive days was well tolerated and produced clinically relevant sustained clearance and long-term reduction in actinic keratoses.
The aesthetic outcome of a scar after surgery has been shown to be the most important predictor of a patient's overall assessment of skin cancer treatment. A higher level of patient dissatisfaction has been noted with wounds on the trunk compared with the face, often because of scar widening. In this prospective, randomized, controlled trial, Kia et al demonstrate that an intradermal suture material with a prolonged lifetime led to significantly decreased scar spread but an increased rate of noted suture reaction at 3 months. These data suggest that further studies into less reactive, longer-acting biomaterials are needed.
In This Issue of JAMA Dermatology. JAMA Dermatol. 2013;149(6):659. doi:10.1001/jamadermatol.2013.20
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