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Xiong MY, Korgavkar K, DiGiovanna JJ, Weinstock MA, for the Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial Group. Fluorouracil and Other Predictors of Morpheaform Basal Cell Carcinoma Among High-Risk Patients: The Veterans Affairs Topical Tretinoin Chemoprevention Trial. JAMA Dermatol. 2014;150(3):332–334. doi:10.1001/jamadermatol.2013.5619
Although basal cell carcinoma (BCC) overall is less aggressive than other forms of skin cancer, the morpheaform subtype is particularly concerning because of its benign appearance and aggressive subclinical spread. We sought to evaluate risk factors for its development on the face or ears in a high-risk population of veterans with at least 2 prior keratinocyte carcinomas in the Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial.
The VATTC Trial included 1131 high-risk veterans followed up for 2 to 6 years, as described elsewhere.1 We determined risk factors for time to first morpheaform BCC (mBCC) within the entire study population via Cox regression (measured by hazard rate ratio [HRR]) and also compared the risk of developing mBCC relative to that of developing nonmorpheaform BCC (nmBCC) via logistic regression (measured by odds ratios [ORs]). All variables with P values <.15 in the univariate models were included in the multivariate backward stepwise regression models. The study was approved by multiple ethics and oversight committees; informed consent was obtained for this study.
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