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In This Issue of JAMA Dermatology
December 2014


JAMA Dermatol. 2014;150(12):1247. doi:10.1001/jamadermatol.2013.6570

Hidradenitis suppurativa (HS) is a chronic debilitating skin disease producing inflamed nodules in apocrine gland–bearing skin. Treatment is often inadequate, and pain and suppuration lead to inactivity, depression, and impaired quality of life. The pandemic cluster of cardiovascular risk factors called the metabolic syndrome (MetS) occurs more commonly with chronic inflammatory diseases. In this cross-sectional study, Miller et al demonstrate that HS appears to be associated with MetS, indicating substantial comorbidities. These data suggest that patients with HS require general medical attention beyond the skin.


Actinic keratoses (AKs) are widely recognized as having the potential to transform to cutaneous squamous cell carcinomas (SCCs). Many treatments exist, and photodynamic therapy (PDT) has become increasingly popular, with reported high rates of efficacy and claims of improved cosmetic outcomes. In this meta-analysis, Patel et al demonstrate that PDT has a 14% better chance of complete lesion clearance at 3 months than cryotherapy for thin AKs on the face and scalp. The long-term efficacy of these techniques in reducing the incidence of SCCs remains unproven.