Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012 | Cancer Screening, Prevention, Control | JAMA Dermatology | JAMA Network
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1.
Karimkhani  C, Boyers  LN, Dellavalle  RP, Weinstock  MA.  It’s time for “keratinocyte carcinoma” to replace the term “nonmelanoma skin cancer.”  J Am Acad Dermatol. 2015;72(1):186-187.PubMedGoogle ScholarCrossref
2.
Rogers  HW, Weinstock  MA, Harris  AR,  et al.  Incidence estimate of nonmelanoma skin cancer in the United States, 2006.  Arch Dermatol. 2010;146(3):283-287.PubMedGoogle ScholarCrossref
3.
Miller  DL, Weinstock  MA.  Nonmelanoma skin cancer in the United States: incidence.  J Am Acad Dermatol. 1994;30(5, pt 1):774-778.PubMedGoogle ScholarCrossref
4.
Guy  GP  Jr, Machlin  SR, Ekwueme  DU, Yabroff  KR.  Prevalence and costs of skin cancer treatment in the U.S., 2002-2006 and 2007-2011.  Am J Prev Med. 2015;48(2):183-187.PubMedGoogle ScholarCrossref
5.
Stern  RS.  Prevalence of a history of skin cancer in 2007: results of an incidence-based model.  Arch Dermatol. 2010;146(3):279-282.PubMedGoogle ScholarCrossref
6.
Wu  S, Han  J, Li  WQ, Li  T, Qureshi  AA.  Basal-cell carcinoma incidence and associated risk factors in U.S. women and men.  Am J Epidemiol. 2013;178(6):890-897.PubMedGoogle ScholarCrossref
7.
Wysong  A, Linos  E, Hernandez-Boussard  T, Arron  ST, Gladstone  H, Tang  JY.  Nonmelanoma skin cancer visits and procedure patterns in a nationally representative sample: national ambulatory medical care survey 1995-2007.  Dermatol Surg. 2013;39(4):596-602.PubMedGoogle ScholarCrossref
8.
American Cancer Society.  American Cancer Society website.http://www.cancer.org/index. Accessed January 5, 2015.
9.
Housman  TS, Feldman  SR, Williford  PM,  et al.  Skin cancer is among the most costly of all cancers to treat for the Medicare population.  J Am Acad Dermatol. 2003;48(3):425-429.PubMedGoogle ScholarCrossref
10.
Joseph  AK, Mark  TL, Mueller  C.  The period prevalence and costs of treating nonmelanoma skin cancers in patients over 65 years of age covered by Medicare.  Dermatol Surg. 2001;27(11):955-959.PubMedGoogle Scholar
11.
Centers for Medicare and Medicaid Services.  Physician/Supplier Procedure Summary Master File.http://www.cms.gov/Research-Statistics-Data-and-Systems/Files-for-Order/NonIdentifiableDataFiles/PhysicianSupplierProcedureSummaryMasterFile.html. Accessed January 5, 2015.
12.
Care  H.  Financing Review 2012 Statistical Supplement (HCFR), 2013.http://www.cms.gov/Research-Statistics-Data-and-Systems/Statistics-Trends-and-Reports/MedicareMedicaidStatSupp/2013.html. Accessed January 3, 2015.
13.
US Census Bureau. American Fact Finder. http://factfinder.census.gov/faces/nav/jsf/pages/index.xhtml. Accessed January 5, 2015.
14.
Elder  DE, ed.  Lever’s Histopathology of the Skin.10th ed. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Williams; 2008.
15.
Staples  M, Marks  R, Giles  G.  Trends in the incidence of non-melanocytic skin cancer (NMSC) treated in Australia 1985-1995: are primary prevention programs starting to have an effect?  Int J Cancer. 1998;78(2):144-148.PubMedGoogle ScholarCrossref
16.
Casey  AS, Kennedy  CE, Goldman  GD.  Mohs micrographic surgery: How ACMS fellowship directors practice.  Dermatol Surg. 2009;35(5):747-756.PubMedGoogle ScholarCrossref
17.
Nestor  MS, Zarraga  MB.  The incidence of nonmelanoma skin cancers and actinic keratoses in South Florida.  J Clin Aesthet Dermatol. 2012;5(4):20-24.PubMedGoogle Scholar
18.
Christenson  LJ, Borrowman  TA, Vachon  CM,  et al.  Incidence of basal cell and squamous cell carcinomas in a population younger than 40 years.  JAMA. 2005;294(6):681-690.PubMedGoogle ScholarCrossref
19.
Kaldor  J, Shugg  D, Young  B, Dwyer  T, Wang  YG.  Non-melanoma skin cancer: ten years of cancer-registry-based surveillance.  Int J Cancer. 1993;53(6):886-891.PubMedGoogle ScholarCrossref
20.
Ackerman  AB, Mones  JM.  Solar (actinic) keratosis is squamous cell carcinoma.  Br J Dermatol. 2006;155(1):9-22.PubMedGoogle ScholarCrossref
21.
Terrill  PJ, Fairbanks  S, Bailey  M.  Is there just one lesion? the need for whole body skin examination in patients presenting with non-melanocytic skin cancer.  ANZ J Surg. 2009;79(10):707-712.PubMedGoogle ScholarCrossref
22.
Lushniak  BD, Koh  HK, Frieden  TR,  et al.  The Surgeon General’s Call to Action to Prevent Skin Cancer. http://www.surgeongeneral.gov/library/calls/prevent-skin-cancer/call-to-action-prevent-skin-cancer.pdf. Accessed January 5, 2015.
Original Investigation
October 2015

Incidence Estimate of Nonmelanoma Skin Cancer (Keratinocyte Carcinomas) in the US Population, 2012

Author Affiliations
  • 1Advanced Dermatology, Norwich, Connecticut
  • 2Department of Dermatology, Brown University, Providence, Rhode Island
  • 3Department of Epidemiology, Brown University, Providence, Rhode Island
  • 4Center for Dermatoepidemiology, VA Medical Center, Providence, Rhode Island
  • 5Department of Dermatology Rhode Island Hospital, Providence, Rhode Island
  • 6Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, North Carolina
  • 7Department of Dermatology, University of Cincinnati Hospital, Cincinnati, Ohio
JAMA Dermatol. 2015;151(10):1081-1086. doi:10.1001/jamadermatol.2015.1187
Abstract

Importance  Understanding skin cancer incidence is critical for planning prevention and treatment strategies and allocating medical resources. However, owing to lack of national reporting and previously nonspecific diagnosis classification, accurate measurement of the US incidence of nonmelanoma skin cancer (NMSC) has been difficult.

Objective  To estimate the incidence of NMSC (keratinocyte carcinomas) in the US population in 2012 and the incidence of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in the 2012 Medicare fee-for-service population.

Design, Setting, and Participants  This study analyzes US government administrative data including the Centers for Medicare & Medicaid Services Physicians Claims databases to calculate totals of skin cancer procedures performed for Medicare beneficiaries from 2006 through 2012 and related parameters. The population-based National Ambulatory Medical Care Survey database was used to estimate NMSC-related office visits for 2012. We combined these analyses to estimate totals of new skin cancer diagnoses and affected individuals in the overall US population.

Main Outcomes and Measures  Incidence of NMSC in the US population in 2012 and BCC and SCC in the 2012 Medicare fee-for-service population.

Results  The total number of procedures for skin cancer in the Medicare fee-for-service population increased by 13% from 2 048 517 in 2006 to 2 321 058 in 2012. The age-adjusted skin cancer procedure rate per 100 000 beneficiaries increased from 6075 in 2006 to 7320 in 2012. The number of procedures in Medicare beneficiaries specific for NMSC increased by 14% from 1 918 340 in 2006 to 2 191 100 in 2012. The number of persons with at least 1 procedure for NMSC increased by 14% (from 1 177 618 to 1 336 800) from 2006 through 2012. In the 2012 Medicare fee-for-service population, the age-adjusted procedure rate for BCC and SCC were 3280 and 3278 per 100 000 beneficiaries, respectively. The ratio of BCC to SCC treated in Medicare beneficiaries was 1.0. We estimate the total number of NMSCs in the US population in 2012 at 5 434 193 and the total number of persons in the United States treated for NMSC at 3 315 554.

Conclusions and Relevance  This study is a thorough nationwide estimate of the incidence of NMSC and provides evidence of continued increases in numbers of skin cancer diagnoses and affected patients in the United States. This study also demonstrates equal incidence rates for BCC and SCC in the Medicare population.

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