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Costa A, Mackelfresh J, Gilbert L, Bonner MY, Arbiser JL. Activation of Protein Kinase C ε in Merkel Cell Polyomavirus–Induced Merkel Cell Carcinoma. JAMA Dermatol. 2017;153(9):931–932. doi:10.1001/jamadermatol.2017.1296
Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin1 that has a maximal incidence in elderly and immunocompromised patients. As the number of elderly and immunocompromised patients continues to rise, the incidence of MCC is rising as well. Radiation, chemotherapy, surgery, and now immunotherapy have been used against MCC.2 While advances have been made, a better understanding of its signaling is required for cure of MCC.3 We found that activated protein kinase C ε (phospho-PKCε) is highly associated with Merkel cell carcinoma–associated polyoma virus (MCPyV), and that this pathway might be a druggable target for polyoma-induced malignancy.
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