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Research Letter
September 2017

Activation of Protein Kinase C ε in Merkel Cell Polyomavirus–Induced Merkel Cell Carcinoma

Author Affiliations
  • 1Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia
  • 2Atlanta Veterans Administration Medical Center, Atlanta, Georgia
  • 3Department of Pathology, Emory University School of Medicine, Atlanta, Georgia
JAMA Dermatol. 2017;153(9):931-932. doi:10.1001/jamadermatol.2017.1296

Merkel cell carcinoma (MCC) is a rare neuroendocrine tumor of the skin1 that has a maximal incidence in elderly and immunocompromised patients. As the number of elderly and immunocompromised patients continues to rise, the incidence of MCC is rising as well. Radiation, chemotherapy, surgery, and now immunotherapy have been used against MCC.2 While advances have been made, a better understanding of its signaling is required for cure of MCC.3 We found that activated protein kinase C ε (phospho-PKCε) is highly associated with Merkel cell carcinoma–associated polyoma virus (MCPyV), and that this pathway might be a druggable target for polyoma-induced malignancy.

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