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Research Letter
April 2018

Health-Related Quality of Life in Patients With Frontal Fibrosing Alopecia

Author Affiliations
  • 1Dermatology Department, Ramon y Cajal University Hospital, Madrid, Spain
  • 2Department of Medicina and Medical Specialties, University of Alcalá, Alcalá de Henares, Madrid, Spain
JAMA Dermatol. 2018;154(4):479-480. doi:10.1001/jamadermatol.2017.6330

Alopecia has a negative association with health-related quality of life (HRQOL).1,2 To our knowledge, there are no large studies focusing on HRQOL in patients with frontal fibrosing alopecia (FFA). The aim of our study was to describe the association between HRQOL, psychological distress, and perception of disease in a large series of patients with FFA.

We designed a descriptive cross-sectional study including patients diagnosed with FFA in our center from January 1, 2016, to February 28, 2017. The institutional review board at Ramon y Cajal University Hospital approved the study, and participants provided oral informed consent. Calculations determined a total sample size of 80 patients to provide 80% power with a type I error of .05. Demographic and clinical characteristics were collected.3 We used the following questionnaires: the Dermatology Life Quality Index (DLQI), the Hospital Anxiety and Depression Scale (HADS), and the Revised Illness Perception Questionnaire (IPQ-R). All 3 tools are validated methods for evaluating dermatology-specific HRQOL, self-reported measure of anxiety and depression, and perception of disease, respectively.4,5 Scoring for the measures is described in the Table. For comparison between groups, we used the Pearson correlation coefficient or χ2 test, as appropriate. All given P values are 2-tailed and P <.05 indicates statistical significance. Statistical analysis was conducted with SPSS, version 19.0 (SPSS Inc).

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