Cutavirus Infection in Primary Cutaneous B- and T-Cell Lymphoma | Allergy and Clinical Immunology | JAMA Dermatology | JAMA Network
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Research Letter
August 2018

Cutavirus Infection in Primary Cutaneous B- and T-Cell Lymphoma

Author Affiliations
  • 1Department of Dermatology, Venerology and Allergology, HELIOS St Elisabeth Hospital Oberhausen, University Witten/Herdecke, Oberhausen, Germany
  • 2Institute of Pathology, Mülheim an der Ruhr, Mülheim, Germany
  • 3Institute of Virology, National Reference Center for Papilloma-and Polyomaviruses, University of Cologne, Cologne, Germany
JAMA Dermatol. 2018;154(8):965-967. doi:10.1001/jamadermatol.2018.1628

For decades, infectious agents, in particular viruses, have been postulated as potential antigenic stimulators in the pathogenesis of primary cutaneous lymphomas, leading to clonal expansion of T-cells and malignant transformation.1 However, all of the so far suspected viruses including retroviruses, herpesviruses, and polyomaviruses have failed to reveal a consistent association with both cutaneous B-cell lymphoma (CBCL) and cutaneous T-cell lymphoma (CTCL).1 Recently, a novel parvovirus named cutavirus was discovered in human fecal samples and in 4 lesional biopsy specimens of patients with mycosis fungoides (MF).2 Therefore, we initiated a retrospective virological study to screen for the presence of cutavirus DNA in a large number of lesional skin samples from patients with different types of CBCL and CTCL.