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In This Issue of JAMA Dermatology
December 2018


JAMA Dermatol. 2018;154(12):1371. doi:10.1001/jamadermatol.2017.3868


In this cohort study of participants in the Nurses’ Health Study II, Li et al identified 4945 incident cases of rosacea and found a significant inverse association between risk of rosacea and increased caffeine intake, particularly from coffee. This association was not found for caffeine from other food sources (eg, tea, soda, chocolate). These findings do not support limiting caffeine intake to prevent rosacea and may have implications for the causes of and clinical approach to rosacea. Wehner and Linos provide an Editorial.


In this multicenter cohort of 467 moderately dysplastic nevi with positive histologic margins, Kim et al found no cases of cutaneous melanoma at the biopsy site after nearly 7 years’ follow-up. However, 2 or more biopsied dysplastic nevi carried increased risk of a subsequent cutaneous melanoma at another site. Observation of moderately dysplastic nevi with positive margins may be reasonable, and screening for subsequent cutaneous melanoma at other sites seems warranted for those with multiple histologic dysplastic nevi.


Author Audio Interview

In this meta-analysis including nearly 8 million individuals, Fu and colleagues found that patients with psoriasis had a 1.70-fold to 2.53-fold increased risk of developing Crohn disease or ulcerative colitis compared with participants who did not have psoriasis. Psoriasis appears to be associated with inflammatory bowel disease, and gastroenterology consultation may be indicated when patients with psoriasis present with bowel symptoms.

In this cost analysis of 116 topical dermatologic generic drugs, Li and colleagues found an inverse correlation between drug price and number of manufacturers. Drugs with only 1 or 2 manufacturers showed a 33.2% higher median percentage price increase compared with drugs with more than 6 manufacturers. Policies that increase market competition among topical dermatologic generic drugs with a limited number of manufacturers may lead to long-term price reductions.

Clinical Review & Education

In this systematic review, Marks et al found that most included studies supported the use of cold caps or scalp cooling systems to reduce taxane-induced alopecia. Analyzed evidence also indicated that use of frozen gloves and socks was associated with the prevention of taxane-induced nail and skin changes. Further investigation is warranted to establish the routine usage protocols, standard outcome measures, and long-term efficacy and safety for these preventive interventions.

Continuing Medical Education