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In This Issue of JAMA Dermatology
July 2019


JAMA Dermatol. 2019;155(7):771. doi:10.1001/jamadermatol.2018.3523

Moreno and colleagues performed a retrospective cross-sectional study to identify the histological characteristics associated with an invasive component of lentigo maligna melanoma. Incisional partial biopsies were taken from 96 patients with a diagnosis of primary cutaneous melanoma in either the lentigo maligna or lentigo maligna melanoma forms. Biopsy results showed that the presence of rows of melanocytes, subepidermal clefts and nests, and a decreased degree of solar elastosis was associated with an invasive component of the disease. LeBoit provides the Editorial.


Using a retrospective, multicenter cohort study, Colboc and coauthors investigated the location, morphologic features, and chemical composition of calcific uremic arteriolopathy calcifications. Cutaneous biopsy results from 29 patients showed that the calcifications were composed of pure calcium-phosphate apatite, were circumferentially located on small to medium-sized blood vessels, and were associated with interstitial deposits, unlike the control arteriosclerotic vessel calcifications, which had no interstitial deposits and thickened vessel walls, suggesting a different pathogenetic mechanism. Dominguez provides the Editorial.