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In This Issue of JAMA Dermatology
December 2019

Highlights

JAMA Dermatol. 2019;155(12):1333. doi:10.1001/jamadermatol.2018.3548

Research

Lergenmuller and colleagues performed a cohort study of 159 419 women in Norway to investigate the dose-response association of lifetime indoor tanning with squamous cell carcinoma (SCC) risk, the association of duration of use and age at initiation with SCC risk, and the association of age at initiation with age at diagnosis. A significantly higher risk of SCC was found among women with 10 years or less of use and more than 10 years of use, and among women with age at initiation of 30 years or older. These results support development of policies that regulate indoor tanning. Lushniak provides an Editorial.

Editorial

Guttman-Yassky and colleagues conducted a cross-sectional study of 51 children younger than 5 years with moderate to severe atopic dermatitis (AD) and children without AD to assess a minimally invasive approach using tape strips to identify skin biomarkers. Gene and protein expression were evaluated using quantitative real-time polymerase chain reaction and immunohistochemistry. The tape strips provided a minimally invasive alternative for serially evaluating AD-associated cutaneous biomarkers and may prove useful for tracking pediatric AD therapeutic response and predicting future course and comorbidities. Castelo-Soccio provides an Editorial.

Editorial

In this time-effectiveness analysis, Zidane and colleagues used a decision-analytic model set in the German health care system to determine the most cost-effective sequence of induction treatment for moderate to severe plaque psoriasis. They analyzed 5 treatment sequences frequently used in Germany and 4 theoretical sequences starting with a biological agent. Treatment sequences starting with a biological agent were more time effective than the 5 frequently used treatment sequences.

Trafford and colleagues conducted a systematic review and meta-analysis of 58 observational studies to determine the risk of cancer incidence and cancer mortality in people with psoriasis. Results showed that the overall risk of developing cancer was significantly elevated in people with psoriasis and involved a range of site-specific cancers. The risk of cancer mortality was found to be elevated in those with severe psoriasis. Future research examining specific lifestyle factors, treatments, and the inflammatory processes that contribute to psoriasis may help provide additional information on the underlying mechanisms for the apparent increased cancer risk.

In this cohort study, Kushner and colleagues evaluated the association of use of rituximab with remission in patients with pemphigus. The study included 112 patients with pemphigus who were treated with rituximab and underwent at least 12 months of clinical follow-up after the start of therapy. Findings indicated that lymphoma dose regimen, age greater than 65 years, and body mass index of 35 or higher were significantly associated with rate of complete remission off therapy. These findings help inform clinical expectations and merit evaluation in future prospective clinical trials.

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