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Acute febrile neutrophilic dermatosis (Sweet syndrome) is a reactive disorder characterized by painful, erythematous, cutaneous plaques and nodules, the onset of which is accompanied by fever, leukocytosis, and neutrophilia. In this multicenter study, Requena et al describe a series of 41 patients with Sweet syndrome in whom histopathologic analysis revealed an inflammatory infiltrate composed mainly of histiocytoid mononuclear cells that were revealed to be immature myeloid cells. The lesions showed a benign biological behavior and responded promptly to low doses of corticosteroids or nonsteroidal anti-inflammatory drugs.
Localized scleroderma (LS) is characterized by hardening and thickening of the dermis, subcutis, and even underlying soft tissue and bone. There are numerous therapeutic options for LS, but none has proven consistently effective. In this nonrandomized open pilot study, Kreuter et al examined the effects of pulsed intravenous high-dose corticosteroids combined with orally administered low-dose methotrexate therapy in severe LS. Fifteen consecutive patients were treated, and most markedly improved as demonstrated by clinical and ultrasonographic evaluation.
TRAVERS RL. This Month in Archives of Dermatology. Arch Dermatol. 2005;141(7):819. doi:10.1001/archderm.141.7.819
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