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ROBIN L. TRAVERSROBIN L. TRAVERSMD
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. Early-stage MF often responds well to daily applications of topical mechlorethamine, although cutaneous intolerance is a frequent and major adverse reaction that often leads to discontinuation of therapy. In this nonrandomized prospective study, de Quatrebarbes et al demonstrate that a therapeutic regimen of twice-weekly applications of mechlorethamine in combination with topical corticosteroids could be an effective treatment regimen for early-stage MF. Not only was the decreased frequency of application simpler for patients, but it also reduced the incidence of severe cutaneous intolerance reactions.
Standard punch biopsy technique involves closing the surgical wound with nonabsorbable suture material, requiring time and cost for both suture placement and removal. In this prospective, randomized study, Christenson et al demonstrated the equivalence of clinical outcomes with second-intention healing and primary closure of punch biopsy sites. Allowing punch biopsy sites to heal by second intention can help patients avoid activity restrictions associated with a sutured wound as well as the inconvenience of returning for suture removal.
This Month in Archives of Dermatology. Arch Dermatol. 2005;141(9):1069. doi:10.1001/archderm.141.9.1069
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