[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
February 1, 2008

Recurrent Toxin-Mediated Perineal Erythema: Eleven Pediatric Cases

Author Affiliations

Author Affiliations: Division of Dermatology, Department of Specialist and Experimental Clinical Medicine (Drs Patrizi, Raone, Savoia, and Neri), and Department of Pediatrics (Dr Ricci), University of Bologna, Bologna, Italy.

Arch Dermatol. 2008;144(2):239-243. doi:10.1001/archdermatol.2007.47

Background  Recurrent toxin-mediated perineal erythema is a cutaneous disease mediated by superantigens made by staphylococci and streptococci, which, to our knowledge, has only been reported in young adults. We describe recurrent toxin-mediated perineal erythema in 11 children and outline the differences between recurrent toxin-mediated perineal erythema and Kawasaki disease in this age range.

Observations  Eleven children (7 male and 4 female) presented with the sudden appearance of asymptomatic erythema, which was salmonlike in color and rapidly desquamating, involving the perineum in 10 patients and extending to the perianal area in 1 patient. At the onset of the rash, all patients were in good health, although 9 had mild fever for 1 to 2 days before its appearance. Physical examination also revealed an erythema of the hands and feet in 4 patients and strawberry tongue in 7. Two patients had a facial impetigo, and another showed a perianal streptococcal dermatitis. A group A β-hemolytic streptococcus was isolated from the throat in 10 cases and from a perianal culture in 1 case. In 8 cases, resolution was spontaneous, but all patients were treated with systemic antimicrobial therapy for 10 days. Three patients had a personal history of cutaneous rashes on the perineal area during the last years before consultation. Rash recurrence was observed in 3 of the 11 patients at the follow-up examination.

Conclusion  Recurrent toxin-mediated perineal erythema can be observed not only in young adults but also in childhood.