[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Research Letter
April 1, 2008

Correlation of Subjective Self-reported Melanoma Growth Rate With Objective Tumor Proliferation Markers

Arch Dermatol. 2008;144(4):555-556. doi:10.1001/archderm.144.4.555

Previous studies, using patient recall, have suggested that melanoma growth rate may be an independent prognostic marker1 and that rapid growth tends to occur in older men and have nodular morphologic characteristics and a different clinical presentation from other melanomas.2

Retrospective recall of time delay leading up to melanoma diagnosis is regarded by some as unreliable.3 However, there is no other practical method by which to evaluate the evolution of a melanoma from the outset. In a previous study,2 the ratio between Breslow thickness and time interval for a melanoma to develop was used as an estimate for melanoma rate of growth (ROG). This subjective measure of ROG based on patient recall correlated significantly with mitotic rate, an objective measure of melanoma proliferation, indicating the validity of patient recall to provide a surrogate measure of melanoma growth rate.2