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Diamantis ML, Richmond HM, Rady PL, et al. Detection of Human Papillomavirus in Multiple Eccrine Poromas in a Patient With Chronic Graft-vs-Host Disease and Immunosuppression. Arch Dermatol. 2011;147(1):120–122. doi:10.1001/archdermatol.2010.383
A poroma is a benign sweat gland tumor composed of cells with terminal ductal differentiation of either apocrine or eccrine origin. Poromas are usually solitary, slow-growing, skin-colored, sometimes pedunculated papules or plaques. Multiple poromas, or eccrine poromatosis, rarely develop in a widespread distribution: 2 cases of eccrine poromatosis have been reported in the setting of chronic immunosuppression1,2; 3 additional reports document the development of multiple eccrine poromas after external irradiation.3-5
Our patient developed multiple eccrine poromas after treatment with an allogeneic stem cell transplant with complications of graft-vs-host disease (GVHD) requiring long-term immunosuppression. The poromas were tested for human papillomavirus (HPV) DNA by nested polymerase chain reaction (PCR), and results were positive for beta-HPV. An actinic keratosis and a squamous cell carcinoma (SCC) in situ tested by nested PCR were negative for beta-HPV. To our knowledge, this is the first reported case of HPV positivity in eccrine poromas.
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