Sweet's Syndrome and Erythema Nodosum: The Simultaneous Occurrence of 2 Reactive Dermatoses | Allergy and Clinical Immunology | JAMA Dermatology | JAMA Network
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Observation
January 1999

Sweet's Syndrome and Erythema Nodosum: The Simultaneous Occurrence of 2 Reactive Dermatoses

Author Affiliations

From the Penn State Geisinger Health System, Section of Dermatology, Department of Medicine, The Pennsylvania State University College of Medicine, the Milton S. Hershey Medical Center, Hershey.

Arch Dermatol. 1999;135(1):62-66. doi:10.1001/archderm.135.1.62
Abstract

Background  The simultaneous occurrence of Sweet's syndrome (SS) and erythema nodosum (EN) in 1 patient is rare. Our review of the literature revealed only 11 biopsy-proved cases in which the 2 reactive dermatoses occurred together. None were associated with an underlying malignant neoplasm.

Observations  We report a biopsy-proved case of SS and EN occurring simultaneously in a patient with an underlying malignant neoplasm (specifically, acute myelogenous leukemia). We also report another biopsy-proved case of SS and EN occurring simultaneously in a patient with underlying Crohn's disease.

Conclusions  The simultaneous occurrence of SS and EN in 1 patient is rarely reported. Both disorders are reactive dermatoses that share many overlapping features. Although individually distinctive, SS and EN are also part of a growing continuum of reactive dermatoses. Our expanded understanding of the similarities and simultaneous manifestation of SS and EN may help us in the future to identify a common underlying mechanism of pathogenesis.

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