Customize your JAMA Network experience by selecting one or more topics from the list below.
Patients with the atypical mole syndrome have multiple dysplastic nevithat appear to be randomly distributed on certain preferred anatomical sitessuch as the upper back. These dysplastic nevi are thought to be acquired melanocyticnevi that begin appearing at puberty. To our knowledge, the presence of agminatedatypical (dysplastic) nevi has not been reported.
We describe a patient with the atypical mole syndrome who has more than100 melanocytic nevi, many of which are clinically atypical and one of whichproved to be a melanoma. Among his many melanocytic nevi is a cluster of approximately50 nevi that are distributed in an area measuring 5 × 3 cm. The histopathologicfeatures of these nevi are consistent with the diagnosis of "dysplastic nevus."
To our knowledge, agminated atypical (dysplastic) nevi have not beendescribed previously. The presence of agminated atypical (dysplastic) neviin a patient with the atypical mole syndrome can be theorized to arise becauseof loss of heterozygosity.
Marghoob AA, Blum R, Nossa R, Busam KJ, Sachs D, Halpern A. Agminated Atypical (Dysplastic) Nevi: Case Report and Review of the Literature. Arch Dermatol. 2001;137(7):917–920. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-137-7-dob00064
Create a personal account or sign in to: