Agminated Atypical (Dysplastic) Nevi: Case Report and Review of the Literature | Dermatology | JAMA Dermatology | JAMA Network
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Observation
July 2001

Agminated Atypical (Dysplastic) Nevi: Case Report and Review of the Literature

Author Affiliations

From the Dermatology Service, Department of Medicine, Memorial Sloan-KetteringCancer Center, New York, NY (Drs Marghoob, Busam, Sachs, and Halpern); andthe Departments of Dermatology, State University of New York at Stony Brook(Dr Marghoob) and Mount Sinai Medical Center, New York (Ms Blum and Dr Nossa).

Arch Dermatol. 2001;137(7):917-920. doi:10-1001/pubs.Arch Dermatol.-ISSN-0003-987x-137-7-dob00064
Abstract

Background  Patients with the atypical mole syndrome have multiple dysplastic nevithat appear to be randomly distributed on certain preferred anatomical sitessuch as the upper back. These dysplastic nevi are thought to be acquired melanocyticnevi that begin appearing at puberty. To our knowledge, the presence of agminatedatypical (dysplastic) nevi has not been reported.

Observation  We describe a patient with the atypical mole syndrome who has more than100 melanocytic nevi, many of which are clinically atypical and one of whichproved to be a melanoma. Among his many melanocytic nevi is a cluster of approximately50 nevi that are distributed in an area measuring 5 × 3 cm. The histopathologicfeatures of these nevi are consistent with the diagnosis of "dysplastic nevus."

Conclusions  To our knowledge, agminated atypical (dysplastic) nevi have not beendescribed previously. The presence of agminated atypical (dysplastic) neviin a patient with the atypical mole syndrome can be theorized to arise becauseof loss of heterozygosity.

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