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Molecular pathology represents an exciting new arena of laboratory medicine, using genetic information to augment routine histopathologic diagnosis based on morphologic characteristics. With new therapeutic interventions available for the treatment of cutaneous malignancies, the need for more accurate, earlier diagnosis is becoming essential. In fact, failure to diagnose melanoma leads the list of malpractice claims among pathologists. However, even a meticulous histopathologic analysis based on refined morphological criteria does not always permit an unequivocal diagnosis. Bastian et al review some of the molecular techniques that have the potential to play a decisive role in the diagnosis of histologically ambiguous cutaneous tumors.
This Month in Archives of Dermatology. Arch Dermatol. 2001;137(11):1410. doi:10.1001/archderm.137.11.1410
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