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The Cutting Edge
March 2002

Treatment of an Ulcerated Hemangioma With Recombinant Platelet-Derived Growth Factor

Author Affiliations


Arch Dermatol. 2002;138(3):314-316. doi:10.1001/archderm.138.3.314

We report a case of a 7-month-old girl with a large facial hemangioma whose ulceration was successfully treated with 0.01% becaplermin (Regranex [Ortho-McNeil Pharmaceutical, Raritan, NJ], recombinant human platelet-derived growth factor-BB) gel. She was noted to have a hemangioma precursor on her face and a heart murmur at the time of birth. After further evaluation, she was found to have a type 1 interrupted aortic arch, ventricular septic defect, and patent ductus arteriosis, and she subsequently underwent surgery to correct her cardiac anomalies. These associated abnormalities are part of PHACE syndrome: the association of posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities.1