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Urticaria pigmentosa (UP) may be associated with systemic disease. This associated systemic mastocytosis may be indolent or may be associated with a hematologic disorder. What is the natural history of systemic mastocytosis in those patients in whom the UP regresses? On review of the records of 106 patients with adult onset UP, Brockow et al found that, in patients with mastocytosis with an associated hematologic disease, regression of UP may occur even as the bone marrow disease becomes progressively more severe. However, in patients with indolent mastocytosis, regression of the UP often parallels regression of the systemic disease.
This Month in Archives of Dermatology. Arch Dermatol. 2002;138(6):734. doi:10.1001/archderm.138.6.734
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