Viral Disease Transmitted by Laser-Generated Plume (Aerosol) | Infectious Diseases | JAMA Dermatology | JAMA Network
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Study
October 2002

Viral Disease Transmitted by Laser-Generated Plume (Aerosol)

Author Affiliations

From the Departments of Dermatology (Drs Garden and Bakus) and Biomedical Engineering (Dr Garden), Northwestern University, the Divisions of Dermatology and Plastic Surgery, The Children's Memorial Hospital, (Dr Garden) Chicago, Ill; the Department of Medicine, University of Rochester, Rochester, NY (Dr O'Banion); and the Department of Veterinary Science, University of Wisconsin, Madison (Dr Olson).

Arch Dermatol. 2002;138(10):1303-1307. doi:10.1001/archderm.138.10.1303
Abstract

Objective  To evaluate the possibility of disease transmission through liberated plume from virally infected tissue that is exposed to the carbon dioxide laser.

Design  Bovine papillomavirus–induced cutaneous fibropapillomas were exposed to the carbon dioxide laser. Laser settings were within the range of clinically used settings. The laser plume (aerosol) was suctioned and collected and then reinoculated onto the skin of calves.

Setting  University laboratory research center.

Main Outcome Measures  Laser plume viral content and postinoculation tumor growth were analyzed and documented.

Results  Collected laser plume contained papillomavirus DNA in all tested laser settings. The viral DNA was most likely encapsulated. Tumors developed at laser plume–inoculated sites for all laser parameter settings. Histological and biochemical analyses revealed that these tumors were infected with the same virus type as present in the laser plume.

Conclusions  Laser plume has been shown, for the first time to our knowledge, to actually transmit disease. Strict care must be maintained by the laser practitioner to minimize potential health risks, especially when treating viral-induced lesions or patients with viral disease.

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