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Dorr RT, Ertl G, Levine N, et al. Effects of a Superpotent Melanotropic Peptide in Combination With Solar UV Radiation on Tanning of the Skin in Human Volunteers. Arch Dermatol. 2004;140(7):827–835. doi:10.1001/archderm.140.7.827
Three phase 1 clinical trials of a superpotent melanotropic peptide, melanotan-1 (MT-1, or [Nle4-D-Phe7]α-melanocyte-stimulatinghormone) were performed to demonstrate safety for MT-1 therapy combined with UV-B light or sunlight.
Open-label studies at 2 dose levels of MT-1 combined with small doses of UV-B to the neck or buttock or full sunlight to half of the back.
Dermatology clinics at the Arizona Health Sciences Center, Tucson.
The first study randomized 4 subjects to MT-1 (0.08 mg/kg per day subcutaneously) and 4 subjects to injections of isotonic sodium chloride (9%) solution for10 days, followed by neck irradiation with 3 times the minimal erythema dose (MED) of UV-B light. In the next study (n = 12), the MT-1 dosage was increasedto 0.16 mg/kg per day for 10 days, with UV-B radiation (0.25-0.75 MED) given to a buttock site for 5 days during (n = 7) or after (n = 5) MT-1 administration.A final study randomized 8 subjects to 3 to 5 days of sunlight to half ofthe back or to sunlight plus 0.16 mg/kg of MT-1 for 5 days per week for 4weeks.
Tanning in the first study was achieved in 3 of 4 subjects receiving MT-1, and these subjects also had 47% fewer sunburn cells at the irradiated neck site. More skin sites darkened with the higher dose of MT-1 in the second study. In the third study, there was significantly enhanced tanning of theback in the MT-1 group, and this was maintained at least 3 weeks longer than the tanning in the sunlight-only controls, who required 50% more sun-exposuretime for equivalent tanning.
Main Outcome Measure
There were no pathologic findings at any UV-B or sun-exposed sites in any subject. Toxic effects due to MT-1 were minor, consisting of nausea andtransient facial flushing.
Melanotan-1 can be safely combined with UV-B light or sunlight and appears to act synergistically in the tanning response to light.
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