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The Cutting Edge
October 2004

Cytomegalovirus Ulcer: Successful Treatment With Valganciclovir

Author Affiliations

From the Yale University School of Medicine, New Haven, Conn (Ms Lambert and Drs Lazova and Antaya); and Massachusetts General Hospital and Harvard Medical School, Boston (Dr Strasswimmer).



Arch Dermatol. 2004;140(10):1199-1201. doi:10.1001/archderm.140.10.1199

A 47-year-old man with multiple-drug–resistant AIDS was admitted to Yale–New Haven Hospital for evaluation of mental status and neuromotor changes and a 6-week history of a painful, nonhealing, enlarging ulcer on the lower extremity that the patient attributed to minor trauma. The patient had received outpatient wound care and several courses of oral antibiotics, but he was taking neither antiretroviral medications nor prophylaxis for opportunistic infections.

The patient's most recent CD4 cell count was less than 20/µL with a viral load of 715 000 copies/mL. He had a history of successfully treated cytomegalovirus (CMV) retinitis and Pneumocystis carinii pneumonia. On admission, he displayed clinical and radiologic features consistent with cerebral toxoplasmosis. He had no history of diabetes mellitus, peripheral vascular disease, or neuropathic disease.