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October 2004

Association of HLA-DR4 (DRB1*0404) With Human Papillomavirus Infection in Patients With Focal Epithelial Hyperplasia

Author Affiliations

From the Department of Dermatology, Hospital General "Dr Manuel Gea González," Tlalpan, México (Drs García-Corona and Vega-Memije); Departamento de Atención a la Salud, Universidad Autónoma Metropolitana, Coyoacán, México (Dr Mosqueda-Taylor); and Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición "Salvador Zubirán," Tlalpan (Drs Yamamoto-Furusho, Rodríguez-Carreón, Ruiz-Morales, Salgado, and Granados). The authors have no relevant financial interest in this article.

Arch Dermatol. 2004;140(10):1227-1231. doi:10.1001/archderm.140.10.1227

Objectives  To determine gene frequencies of HLA-DR alleles in 22 Mexican patients with focal epithelial hyperplasia and compare them with those present in ethnically matched healthy subjects, as well as to determine the types of human papillomavirus present in the lesions.

Design  Prospective and retrospective observational study.

Setting  Dermatology outpatient clinic in a general hospital.

Patients  Twenty-two patients with clinically and histologically confirmed focal epithelial hyperplasia seen within a 10-year period.

Interventions  None.

Main Outcome Measures  Results of high-resolution DNA typing for HLA-DR alleles and biopsy for viral typing.

Results  HLA-DR4 (DRB1*0404) was significantly increased (P<.001; odds ratio, 3.9; 95% confidence interval, 1.86-8.03). Seventeen (85%) of 20 patients had human papillomavirus subtype 13. The data on human papillomavirus differed from reports elsewhere that described association with human papillomavirus type 32.

Conclusions  The HLA-DRB1*0404 allele suggests that Amerindian populations are at risk, and in this group, the Mexican population studied was affected only by human papillomavirus type 13.