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Article
February 1941

WETTING AGENTS: NEW SYNTHETIC CHEMICALS OF USE IN FINER AND MORE EFFICIENT TOPICAL DERMATOLOGIC THERAPY

Author Affiliations

FORT WAYNE, IND.

Arch Derm Syphilol. 1941;43(2):264-280. doi:10.1001/archderm.1941.01490200044005
Abstract

Studies of the permeability and absorptivity of the skin have engaged the interest of dermatologists from time to time, because since ancient days the management of most cutaneous diseases has been dependent in a large part on local and topical treatment. According to Eller and Wolff,1 these studies have established that:

  1. Medicaments applied to the unbroken skin may be absorbed into the blood stream.

  2. The rate of absorption may be influenced by the vehicle as well as by the drug it contains.

  3. Volatile substances such as alcohol, ether and benzine are vehicles with a much higher rate of absorption than fats.

Eller and Wolff1 in their own studies on permeability and absorptivity of the skin came to the following conclusions:

  1. Fats permeate the skin and do so in a large measure along the hair shafts and into the oil gland ducts.

  2. Liquid fats

References
1.
Eller, J. J., and Wolff, S.:  Permeability and Absorptivity of the Skin ,  Arch. Dermat. & Syph. 40:900 ( (Dec.) ) 1939.
2.
Maynard, M. T. R.:  Triethanolamine: An Adjunct to Dermatologic Therapy ,  Arch. Dermat. & Syph. 25:1041 ( (June) ) 1932
3.
34:268 (Aug.) 1936.
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Goodman, H.:  Cosmetic Dermatology: I. Triethanolamine ,  Arch. Dermat. & Syph. 36:116 ( (July) ) 1937.
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Gross, E. R.:  Ointment Bases , read at the  meeting of the American Academy of Dermatology, Philadelphia, Nov. 7, 1939 .
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Klauder, J. V.; Gross, E. R., and Brown, H.:  Prevention of Industrial Dermatitis ,  Arch. Dermat. & Syph. 41:331 ( (Feb.) ) 1940.
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Bartell, F. E.:  Surface-Active Agents ,  Indust. & Engin. Chem. 31:31 ( (Jan.) ) 1939.
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 Am. A. Textile Chemists & Colorists ,  Yearbook 13:162, 1935-1936.
9.
Jaeger, A. O.: United States Patent 2,028,091, 1936.
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Caryl, C. R., and Ericks, W. P.:  Esters of Sodium Sulfosuccinic Acid ,  Indust. & Engin. Chem. 31:44 ( (Jan.) ) 1939.
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Langmuir, I.:  The Shapes of Group Molecules Forming the Surface of Liquids ,  Proc. Nat. Acad. Sc. 3:251, 1917.
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Wilkes, B. G., and Wickert, J. N.:  Synthetic Aliphatic Penetrants ,  Indust. & Engin. Chem. 29:1234 ( (Nov.) ) 1937.
13.
Aerosol Wetting Agents, New York, American Cyanamid and Chemical Corporation.
14.
Bergy, G. A.:  New Compounds in Pharmacy Practice: Wetting Agents ,  Am. Professional Pharmacist 5:18 ( (Jan.) ); 17 (Feb.); 140 (March); 430 (April); 494 (May) 1939.
15.
 Organic Chemical Specialties , Bulletin la, Wilmington, Del., E. I. du Pont de Nemours & Co., Inc., 1939.
16.
The finished product can be obtained from the Hickok Chemical Company, Detroit.
17.
 Bulletin Organic Chemicals Department , Wilmington, Del., E. I. du Pont de Nemours & Co., Inc., 1940.
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