[Skip to Content]
Sign In
Individual Sign In
Create an Account
Institutional Sign In
OpenAthens Shibboleth
[Skip to Content Landing]
Article
June 1941

SKIN RESPIRATION AS A DERMATOLOGIC TOOL

Author Affiliations

Attending Dermatologist, Skin and Cancer Unit of the New York Post-Graduate Medical School and Hospital NEW YORK; CINCINNATI

From the Institutum Divi Thomae.

Arch Derm Syphilol. 1941;43(6):949-955. doi:10.1001/archderm.1941.01490240029004
Abstract

In dermatology there is need for a quantitative criterion of the physiologic condition of the skin. Much dermatologic diagnosis depends on close observation and, in the last analysis, on the experience and judgment of the physician. It would be desirable to supplement this procedure by a more objective method by which variations in cutaneous vitality could be measured. It has been suggested by Adams1 and by Cook2 that the respiration of skin may be such a criterion. It is the object of this and succeeding papers to discuss the measurement of the respiration of human skin, its variation with different physiologic conditions and the effect of various toxic agents on it.

There is already a background of experimental data relating various pathologic conditions and the action of toxic agents on the respiration of skin. For example, Kadisch3 has shown a relation between the localization of infections, the

References
1.
Adams, P. D.:  Effect of Age on Consumption of Oxygen and Composition of the Skin of the Albino Rat ,  Arch. Dermat. & Syph. 36:606-610 ( (Sept.) ) 1936.
2.
Cook, E. S.:  Skin Health and Respiration ,  Chem. Products 1:65-67 ( (Jan.) ) 1939
3.
2:89-92 (Aug.) 1939.
4.
Kadisch, E.:  Der Einfluss von Temperatur und Sauerstoff auf die Lokalisation der Infektionen ,  Arch. f. Dermat. u. Syph. 168:438-476, 1933.
5.
Warburg, O.:  The Metabolism of Tumours , London, Constable & Co., Ltd., 1930.
6.
Dickens, F.:  Metabolism of Tumours ,  Nature, London 145:512 ( (March 30) ) 1940.
7.
Dickens, F., and Weil-Malherbe, H.:  Carbohydrate Metabolism of Tumours ,  Nature, London 145:779 ( (May 18) ) 1940.
8.
Cook, E. S.; Hart, Sister Mary Jane, and Joly, R. A.:  The Effect of 1, 2, 5, 6-Dibenzanthracene on the Growth and Respiration of Yeast ,  Science 87:331 ( (April 8) ) 1938
9.
 Am. J. Cancer 35:543-545 ( (April) ) 1939.
10.
Pourbaix, Y.:  Etude de l'influence du 1-2, 5-6, dibènzene anthracene sur le métabolisme cellulaire des hydrates de carbone ,  Compt. rend. Soc. de biol. 110:1015-1018, 1932
11.
 Etude de l'influence d'un corps cancérigène, le 1-2,5-6 dibenzène anthracène, sur la respiration de la cellule normale , Pourbaix Compt. rend. Soc. de biol. 112:1222-1225, 1933
12.
 Respiration des coupes de cerveau in vitro en présence d'un corps pur cancérigène, le 1-2,5-6 dibenzène anthracéne , Pourbaix Compt. rend. Soc. de biol. 113:930-933, 1933
13.
 Sur le métabolisme cellulaire des hydrates de carbone , Pourbaix sur la respiration de la cellule normale 115:1738-1739, 1934.
14.
Fardon, J. D.; Brotzge, G. C., and Loeffler, Sister M. Kenneth: Unpublished data.
15.
Fardon, J. C., and Sullivan, W. A.:  Respiration Changes Following Irradiation with X-Rays ,  Nature, London 143:287 ( (Feb. 18) ) 1939.
16.
Fardon, J. C.; Sullivan, W. A.; Brotzge, G. C.; Loeffler, Sister M. Kenneth, and Andrus, Sister Mary Basilia:  Changes in Respiration Following Irradiation with X-Rays ,  Studies Inst. Div. Thom. 2:203-214 ( (Nov.) ) 1939.
17.
Sure, B., and De Witt, J. B.:  The Oxygen Uptake of Tissues in Vitamin Deficiencies ,  J. Biol. Chem. 126:287-298 ( (Nov.) ) 1938.
18.
Presnell, A. K.:  The Relation of Vitamin D to Skin Respiration ,  J. Biol. Chem. 121:5-8 ( (Oct.) ) 1937.
19.
Bommer, S.:  Haut und Vitamine ,  Deutsche med. Wchnschr. 60:570 ( (April 13) ) 1934.
20.
Adams, P. D.:  The Oxygen Uptake and Composition of the Skin of Rats in Vitamin G Deficiency ,  J. Biol. Chem. 116:641-651 ( (Dec.) ) 1936.
21.
Kinnersley, H. W., and Peters, R. A.:  Observations upon Carbohydrate Metabolism in Birds ,  Biochem. J. 23:1126-1136, 1929.
22.
Passmore, R.; Peters, R. A., and Sinclair, H. M.:  On Catatorulin: A New Method of Comparing the Oxidative Factor in Vitamin Bi Concentrates , Kinnersley Biochem. J. 27:842-850, 1933.
23.
Peters, R. A.; Rydin, H., and Thompson, R. H. S.:  Brain Respiration, a Chain of Reactions, as Revealed by Experiments upon the Catatorulin Effect ,  Biochem. J. 29:53-62, 1935.
24.
O'Brien, J. R., and Peters, R. A.:  Vitamin B1 Deficiency in the Rat Brain ,  J. Physiol. 85:454-463, 1935.
25.
Banga, I.; Ochoa, S., and Peters, R. A.:  Pyruvate Oxidation in Brain: VI. The Active Form of Vitamin B1 and the Role of C4 Dicarboxylic Acids ,  Biochem. J. 33:1109-1121 ( (July) ) 1939.
26.
Hastings, A. B.; Muus, J., and Bessey, O. A.:  Tissue Metabolism in Vitamin Deficiencies: I. Effect of Deficiencies in Riboflavin and Other Heat-Stable Vitamin B Components ,  J. Biol. Chem. 129:295-301 ( (July) ) 1939.
27.
Muus, J.; Weiss, S., and Hastings, A. B.:  Tissue Metabolism in Vitamin Deficiencies: II. Effect of Thiamine Deficiency ,  J. Biol. Chem. 129:303-307 ( (July) ) 1939.
28.
Borsook, H.; Davenport, H. W.; Jeffreys, C. E. P., and Warner, R. C.:  The Oxidation of Ascorbic Acid and Its Reduction in Vitro and in Vivo ,  J. Biol. Chem. 117:237-279 ( (Jan.) ) 1937.
29.
Stotz, E.; Harrer, G. J.; Schultze, M. O., and King, C. G.:  Tissue Respiration Studies on Normal and Scorbutic Guinea Pig Liver and Kidney ,  J. Biol. Chem. 120:129-140 ( (Aug.) ) 1937.
30.
Bronfenbrenner, J.; Hershey, A. D., and Doubly, J. A.:  Evaluation of Germicides by a Manometric Method ,  Proc. Soc. Exper. Biol. & Med. 38:210-212 ( (March) ) 1938
31.
 J. Bact. 37:583-597 ( (June) ) 1939.
32.
Ely, J. O.:  The Evaluation of Germicides by a Manometric Method ,  J. Bact. 38:391-400 ( (Oct.) ) 1939.
33.
Henderson, V. E.:  The Present Status of the Theories of Narcosis ,  Physiol. Rev. 10:171-220 ( (April) ) 1930.
34.
Kisch, B.:  Das pH-Optimum der Atmungsgrösse verschiedener Gewebe ,  Biochem. Ztschr. 253:377-378, 1932.
35.
Tarantino, C.:  Oxygen Consumption of Tissues as a Function of Hydrogen Ion Concentration of the Media ,  Riv. di biol. 23:281-290, 1937.
36.
Ruddy, Sister Mary Veronita: Unpublished data.
37.
Cook, E. S., and Kreke, C. W.:  Fatty Acids from Yeast as Respiratory Factors ,  Nature, London 142:719 ( (Oct. 15) ) 1938
38.
 A Note on a Solid from Yeast Which Affects Cellular Metabolism ,  Studies Inst. Div. Thom. 2:47-49 ( (Nov.) ) 1938
39.
 Respiratory Activity of a Steam Distillate from Yeast ,  Studies Inst. Div. Thom. 2:215-225 ( (Nov.) ) 1939.
40.
Cook, E. S., and Morgan, Sister Mary Norbert:  The Effect of Some Saturated Fatty Acids on the Respiration of Baker's Yeast ,  Biochem. J. 34:15-20 ( (Jan.) ) 1940.
41.
Peters, R. A., and Wakelin, R. W.:  The Dissociating Power of Salts of Fatty Acids ,  Biochem. J. 32:2290-2295 ( (Dec.) ) 1938.
42.
Dixon, M.:  Manometric Methods , London, Cambridge University Press, 1934.
43.
Cook, E. S.; Kreke, C. W., and Nutini, L. G.:  Fractions from Yeast Which Stimulate the Respiration of Yeast and Animal Tissues ,  Studies Inst. Div. Thom. 2:23-37 ( (Nov.) ) 1938.
44.
Wohlgemuth, J., and Klopstock, E.:  Die Fermente der Haut: V. Atmung und Glycolyse der Haut und ihre Beeinflussung durch Hormone ,  Biochem. Ztschr. 175:202-215, 1926.
×