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Article
December 1941

HYPOSENSITIZATION TO POISON IVY

Author Affiliations

DALLAS, TEXAS

From the Department of Dermatology and Syphilology, Baylor University College of Medicine, Dallas, Texas.

Arch Derm Syphilol. 1941;44(6):983-998. doi:10.1001/archderm.1941.01500060002001
Abstract

During the past three years specific oleoresins have been administered intramuscularly or orally to some 40 persons who suffered recurrent seasonal dermatitis from contact with one or more allergenic weeds.

Because of unsatisfactory clinical results, intramuscular administration of the excitant was discontinued after one season. The severity of local reactions prevented injection of the antigenic oils except in high dilutions. A study of the case records shows that the maximum amount of oil administered to a single patient during an entire season was equivalent to less than 0.4 cc. of the solvent-free specific oleoresin. If persons were willing to submit to daily multiple injections, clinical results would probably equal those obtained from oral therapy. None of my patients has submitted to even semiweekly injections of the oil for nine to ten months, the period during which oral therapy has usually been administered daily.

Satisfactory clinical results were obtained in approximately

References
1.
Shelmire, B.:  Contact Dermatitis from Weeds: Patch Testing with Their Oleoresins ,  J. A. M. A. 113:1085 ( (Sept. 16) ) 1939.Crossref
2.
Shelmire, B.:  Nature of the Excitant of Poison Ivy Dermatitis ,  Arch. Dermat. & Syph. 42:405 ( (Sept.) ) 1940.
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Shelmire, B.:  Cutaneous and Systemic Reactions Observed During Oral Poison Ivy Therapy ,  J. Allergy 12:252 ( (March) ) 1941.
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Schamberg, J. F.:  Desensitization of Persons Against Poison Ivy ,  J. A. M. A. 73:1213 ( (Oct. 18) ) 1919.
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Attix, J. C.: Ivy Poisoning and Its Treatment: Prophylaxis, M. World, July 1912; cited from a reprint furnished by the author.
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Spain, W. C., and Cook, R. A.:  Dermatitis Venenata: Observations upon the Use of a Modified Extract from Toxicodendron Radicans ,  J. Immunol. 12:93, 1927.
7.
Shelmire, B.: Unpublished data.
8.
Greenberg, S., and Mallozzi, E. D.:  Experiments in Poison Ivy Sensitivity: Effects of Specific Injections on the Level of Sensitivity to Quantitative Patch Tests and on Clinical Sensitivity ,  Arch. Dermat. & Syph. 42:290 ( (Aug.) ) 1940.
9.
In the presence of two members of the American Dermatological Association, Dr. E. C. Fox and Dr. A. G. Schoch.
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